Clinical features

• Familial tendency, 20% affected parents
• Especially male children 

[Ramstedt pyloromyotomy] 

Pathophysiology of Alkalosis in Pyloric stenosis

1. Stomach: Loss of gastric acid secretions (rich in protons and chloride)
2. Pancreas: Reduced pancreatic juice secretion (reduced load in duodenum) - Pancreatic juice rich in bicarbonate which is retained
3. Volume depletion maintains alkalosis by leading to bicarbonate absorption over chloride
4. Kidneys: Increased uptake of bicarbonate at renal tubules (due to loss of chloride) to maintain electrochemical neutrality