Immediate / Anaphylactic IgE linkage by an antigen leads to release of mast cell contents (histamine, 5HT, heparin, PAF, chemokines)
Minutes
Eg. eczema, asthma, allergic rhinitis
Type II
Cytotoxic Antibody in serum reacts against tissue components resulting in cell death from (1) complement action (2) destruction by killer T-cells (3) phagocytosis by macrophages
Minutes-hours
Eg. transfusion reactions
Type III
Immune complex Immune complex formed that activates complement/platelets - cause damage by formation of membrane attack complex (MAC) and enzyme release from inflammatory cells