#Polycystic #kidney #illness #pathology #Straightforward #explaination #MBBS
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#polycystickidneydisease
#pathology
#mbbs
#neetpg
#nextpg
#usmle
#kidneypathology
#fmge
#india
#quickreview
#Apkd
#autosomaldominant
#autosomalrecessive
#Adultpolycystickidneydisease
#PKD
#childhoodpolycystickidneydisease
POLYCYSTIC KIDNEY DISEASE (PKD)
A. Inherited defect resulting in bilateral enlarged kidneys with cysts within the renal cortex
and medulla
B. Autosomal recessive kind presents in infants as worsening renal failure and
hypertension; newborns might current with Potter sequence.
1. Related to congenital hepatic fibrosis (results in portal hypertension) and
hepatic cysts
C. Autosomal dominant kind presents in younger adults as hypertension (attributable to
elevated renin), hematuria, and worsening renal failure.
1. As a consequence of mutation within the APKD1 or APKD2 gene; cysts develop over time.
2. Related to berry aneurysm, hepatic cysts, and mitral valve prolapse
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