#Methotrexate #Aspect #Results #Mechanism #Motion #Indications
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Methotrexate stays a cornerstone within the remedy of rheumatoid arthritis and different rheumatic ailments. Folate antagonism is understood to contribute to the antiproliferative results which are vital within the motion of methotrexate towards malignant ailments, however concomitant administration of folic or folinic acid doesn’t diminish the anti-inflammatory potential of this agent, which means that different mechanisms of motion could be operative. Though no single mechanism is adequate to account for all of the anti-inflammatory actions of methotrexate, the discharge of adenosine from cells has been demonstrated each in vitro and in vivo. Methotrexate may also confer anti-inflammatory properties by way of the inhibition of polyamines. (See quotation beneath)
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Matter References
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🌎https://www.arthritis.org/health-wellness/remedy/treatment-plan/disease-management/methotrexate-managing-side-effects
🌎https://medlineplus.gov/druginfo/meds/a682019.html
🌎https://www.nhs.uk/medicines/methotrexate/
Description’s Quotation
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Chan ES, Cronstein BN. Methotrexate–how does it actually work? Nat Rev Rheumatol. 2010 Mar;6(3):175-8. doi: 10.1038/nrrheum.2010.5. PMID: 20197777
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