#Heparin #Mnemonic #USMLE
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Heparin is an anticoagulant drug used to stop blood clotting in a wide range of totally different medical contexts. Heparin works by activating antithrombin, which then goes on to inhibit a number of clotting elements. Particularly, the activated types of elements 2 and 10 are inhibited. This results in anticoagulation, which is measured or monitored by an elevation of PTT. In distinction to different anticoagulants, Heparin is taken into account to be secure to make use of throughout being pregnant. Potential unintended effects of heparin embrace extreme bleeding, and Heparin Induced Thrombocytopenia, or HIT. In HIT, antibodies are produced towards a heparin-platelet-factor 4 advanced. This prompts platelets, inflicting a pro-thrombotic state that consumes or makes use of up platelets whereas lowering platelet counts. Importantly, heparin’s results may be reversed by administering protamine sulfate.
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#USMLE #Step1 #Pharm #heparin #bloodclot
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