Metabolism of alcohol

• Microsomal ethanol oxidising system (MEOS)
• Alcohol dehydrogenase
• Catalase 

Biochemistry/Haematology

• Raised GGT
• Macrocytosis 

Laryngeal disease associations

•  Laryngeal inflammation
• SCC larynx
• SCC pharynx / oesophagus

Hepatic effects of chronic alcohol

• Fatty liver
• Alcoholic hepatitis
• Cirrhosis: End stage of all chronic liver insults (1) nodules (2) fibrosis (3) distorted architecture
• Hepatocellular carcinoma

GI associations

• Gastritis/erosions
• Pancreatitis
• Carcinoma of pancreas

CNS effects

• Dis-inhibition, violence, trauma, chronic malnutrition
• Cerebellar degeneration
• Korsakov's psychosis
• Wernicke's: antegrade amnesia (?related to thiamine deficiency)