AIDS

Human Immunodeficiency Virus

  • RNA retrovirus
  • requires reverse transcriptase
  • Core protein RNA surrounded by glycoprotein envelope
  • Infects cells via CD4 receptors (T-helper) 

 

 

 

Neoplastic associations

  1. Lymphoma
    • B-cell NHL / T-cell NHL
    • Aggressive form HL
  2. Kaposi's sarcoma
  3. Skin cancer
    • SCP
    • SCC: anus, vulva
  4. Laryngeal neoplasm
    • SCC larynx

Surgical Relevance

  • Bacterial enteritis
  • Haemorrhage from KS of GIT
  • CMV infection leading to megacolon
  • GIT lymphoma