Effective if given within 12 hours of pain
Cannot achive re-perfusion in all cases
Limited ability to detect reperfusion
High risk of bleeding
| Indications | Contraindications |
|
Presentation within 12 hours of chest pain
|
Haemorrhagic stroke CNS damage / neoplasm Recent surgery (3/52) Active internal bleeding Known / suspected aortic dissection Known bleeding disorder |
Drugs
Streptokinase - takes at least 1 hour to complete (therefore commited to CPR), can cause allergy/anaphylaxis 1.5MU in 100mls N/Saline
Alteplase (R-tpa): more effective than strep, 15mg iv bolus + 0.75mg/kg/1hour
Reteplase
Tenectplase