Streptococcus II | pathogenesis | diagnosis and treatment | medical microbiology lectures

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Pathogenesis
Group A streptococci (S. pyogenes) cause disease by three mechanisms:
Pyogenic inflammation, which is induced locally at the site of the organisms in tissue;
(2) Exotoxin production, which can cause widespread systemic symptoms in areas of the body where there are no organisms; and
(3) Immunologic, which occurs when antibody against a component of the organism cross-reacts with normal tissue or forms immune complexes that damage normal tissue.
The immunologic reactions cause inflammation (e.g., the inflamed joints of rheumatic fever), but there are no organisms in the lesions.
Clinical Findings
Streptococcus pyogenes causes three types of diseases:
Pyogenic diseases such as pharyngitis and cellulitis,
(2) Toxigenic diseases such as scarlet fever and toxic shock syndrome.
(3) Immunologic diseases such as rheumatic fever and acute glomerulonephritis (AGN).
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Streptococcus II | pathogenesis | diagnosis and treatment | medical microbiology lectures

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